Exploiting Gene Expression Kinetics in Conventional Radiotherapy, Hyperfractionation, and Hypofractionation for Targeted Therapy
نویسندگان
چکیده
منابع مشابه
Targeted gene therapy in radiotherapy
Radiotherapy is the use of ionizing radiation in the treatment of malignant tumors. It is one of the main treatment modalities for many forms of cancer, with more than half of all cancer patients receiving radiation therapy at some point in their treatment.1 Biological and technological advances have brought notable improvements in radiotherapy over the years. Biologically based advances includ...
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Breast cancer management has drastically changed since the 1990s. Many patients with breast cancer now can opt to conserve their breast through a lumpectomy and radiation (breast conservation therapy), rather than a full mastectomy. Advances in the techniques of delivery and length of breast radiotherapy have been rapidly evolving. This article attempts to summarize some of those changes for nu...
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2. It is generally assumed that the mechanistic basis for the different fractionation response of tumors and late-responding normal tissues relates to the larger proportion of cycling cells in tumors. However, prostate tumors contain unusually small fractions of cycling cells (19), so back in 1999, Brenner and Hall (1) and Duchesne and Peters (2) reasoned that prostate tumors might not respond ...
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ژورنال
عنوان ژورنال: Seminars in Radiation Oncology
سال: 2016
ISSN: 1053-4296
DOI: 10.1016/j.semradonc.2016.07.001